Protein Details: Gamma-aminobutyric acid receptor subunit alpha-6

Protein ID

ICDB_Pro_1348

Protein Name

Gamma-aminobutyric acid receptor subunit alpha-6

Gene Name

GABRA6

Organism

Gallus gallus (Chicken)

Length

465 amino acids

AlphaFoldDB

AF-Q90845-F1-model_v4.pdb

Function

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA); a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels; also named GABA(A) receptors (GABAAR); consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA; GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity).

Sequence

MALLIAWVCVAVSIEKALGGQGDGGDLYSENITRILDKLLDGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILRLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLHSVEVPQESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQRAMRKAARAAALAAALSAATVPAEDEIVSHSDSNCNLKKRVNSVTSQADQSPEASIVSNSASQCQPVSAPPPAPPAPPPVGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEFFEPTAMHLRNDHQSN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 84; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit"; BINDING 147; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit"

Disease

Location

Expressed in brain; in cerebellar granule cells

DOI ID

10.1046/j.1471-4159.1996.66051810.x

RefSeq

NP_990389.1